I am only giving this movie a 1 for the great cast, though I can't imagine what any of them were thinking. This movie was horrible

The movie turns out to be a little better than the average. Starting from a romantic formula often seen in the cinema, it ends in the most predictable (and somewhat bland) way.

Each character in this movie — down to the smallest one — is an individual rather than a type, prone to spontaneous changes of mood and sometimes amusing outbursts of pettiness or ill humor.

Through painfully honest and emotional moments, the movie becomes irresistibly relatable

It is very difficult to understand why such a bad script got greenlighted. I guess this film is intended to be a "coming of age" comedy. Well, it is not. The characters are almost nameless. A recovering alcoholic-drug addict arquitect in his 30's is bests friends with a jobless woman who complains all the time about being dumped by a guy who once saved her life because he loved her (though later he confesses he did not); an aspiring actress who always fails at her cast appearances because she always has accidents because of the same reason (the architect's manners) and always ends up performing as a bee in a kid's show but... guess what... at the end, she decides to be a flight attendant and her mom gets her an interview with an airline executive who is willing to under-see her small size and her age... but guess what again... just as she was being admitted as a flight attendant, the police bursts in and arrests her for being a drug dealer, because she had a friend in her bee-entertaining-activities that put an heroin dosis in her room to ease her pains... but guess what again... the architect is a womanizer but deep inside he is just a tender guy waiting for his long time love to finally accept him... and guess again... the first gut, the one who saves the heroin, had a girlfriend who was smashed by the same car that smashes his new found love, at the same street, with the same car... really!!! I'm not kiddin'!!! And that's it. All of the above became into a boring, tedious, senseless motion picture.The worst part: this thing made it's way to the theaters. And was co-produced by Warner bros. The first time a US major studio invests in a local production.

I was very impressed by this movie. I decided to see it because someone had labeled this as a romantic comedy ... It's not ... it's something else ... It's a voyage you take into real life with four very strange yet familiar characters ... They are quite well written, with their own obsessions so you get the feeling that you have met people like them before. None of them are at the point they thought they would be by the time the movie starts which makes them turn back to the moment they felt it all started. I'm not going to explain the entire plot because it's not the most important thing about the movie or the reason you will enjoy it. It's the way it makes you feel, the way it makes you think about your own life. In my opinion it's worth seeing . It's romantic, crazy and poetic all at the same time, just like life ...

After seeing Efectos Secundarios, I realize that Issa Lopez is genuinely a well-read, versatile, sharp director and is ready to make her mark as a pioneer of Mexican and hopefully American cinema. Where will all this talent lead her next? It's nice to see a film that pulls from many different philosophies, while having a commercial, yet universal sensibility as well as one native to the environment of Mexico City. Another thing that this film has is an eclectic music score, and an exceptionally modern look for being produced entirely in Mexico. The audience I saw this film with was on the floor in laughter most of the time. A definite recommend.

This film is destined to become a classic of the new golden age of Mexican Cinema. It made me laugh out loud and it made me cry. Writer-director Issa Lopez is clearly the love child that Elaine May, Nora Ephron, Woody Allen, Pedro Almodovar, and Nancy Meyer conceived while vacationing together in Mexico.She learned all she could from this noble parentage, and then developed an original voice that directly reflects the dreams and obstacles of 20-somethings living today -- in Mexico, or anywhere in the world.Her characters are funny, sexy, and endearing and instantly win you over as they figure out who they are and what they are doing with their lives.I can't wait to see Lopez' next film.