"We Ride for Her" follows the dual narratives of two Indigenous women: Lorna and Heather. Lorna is part of an Indigenous motorcycle group and sisterhood called The Medicine Wheel Riders. The sisters organize a ride every year called The Medicine Wheel Ride that brings the issue of Missing and Murdered Indigenous Women (MMIW) to Sturgis Motorcycle Rally, the largest motorcycle rally in the United States. Heather is a travel nurse and devoted mother to her son Khalid. Khalid is in his final year of college and is dedicated to becoming an activist for Indigenous rights. Both Heather and Khalid are searching for their sister and aunt Susan, who went missing a little over a year ago.