People are voting emotionally.

Captivating movie !

Admirable film.

There are moments that feel comical, some horrific, and some downright inspiring but the tonal shifts hardly matter as the end results come to a film that's perfect for this time.

What I most enjoyed and loved about The Perfect 46 was after almost every scene I was left with a question in my mind about the ethics of scientific discovery. As a scientist, I was questioning my own work and pursuit of a new therapy for a debilitating autoimmune disease and the implications of my work. One of the main derivatives of the disease I study is an underlying genetic risk for the disease. There are specific genes that increase susceptibility for the disease in children and although, the subject of The Perfect 46 borders eugenics, the concept of trying to eliminate genetic risk associated with disease does seem like an appealing therapeutic approach. A 'pseudo-dating' genetic screening site may not be the best answer however.From scene to scene I questioned what I would do in each of the conflicts Jesse Darden, the lead, would face- from a scientist and from a citizen perspective. This movie is important now, in this time of increasing advances in genetic sequencing. Ethical issues about what can and should be done with the accumulation of big data from large genetic sequencing studies needs to be addressed. The Perfect 46 thoroughly portrays how our technology is advancing faster than our understanding of its implications. From an artistic perspective, I thoroughly enjoyed the simplicity and nod to retro artifacts in most of the locations in The Perfect 46. It was also interesting to see the character portrayal of a scientist as someone who became quite power and business driven. There are of course many of those types out there, as there are introverted academics that enjoy their quiet magnificent discoveries from behind the lab bench. The Perfect 46 is a well-written, well-directed film that integrates a highly technical scientific discovery in to a refreshing question answer dialogue driven by an unexpected scientist character. This film is a treat to watch and I highly recommend it if you're in to or want to learn more about the repercussions of advancing technologies like this new era of next generation sequencing.

Review -- The Perfect 46 was supposed to be a science fiction movie but, this science is actually fact! There are several start-up companies using the concept of DNA matchmaking today, just google "DNA romance".I felt the directors took this concept in an unlikely direction and turned the idea of DNA matchmaking into Frankenstein's monster. I felt they missed the real value people would see in a DNA based matchmaking. The perfect 46 pretends that DNA based matchmaking will only give health reports and the idea has no other value. Education -- Unlike what is described in the perfect 46 there are no companies offering health based compatibility reports. The approach these DNA matchmaking companies use for compatibility reports is based on opposite HLA genes, meaning the have couple will have biological chemistry, they will find that their partners odor smells sexy.

This film had an interesting concept, but lacked all elements that make a film watchable. The dialogue alone made me want to pull my hair out. It takes question and answer dialogue to a whole new meaningless level. The lead actor had no connection to anything and was excruciating to watch. The ending was so anticlimactic and predictable, but also confusing and cliché'. I'm confused as to what the director was trying to say with this film. There wasn't any address to why the main character wanted this so badly. If he wanted to just help people, why did he charge money for the service? Did he hate having OCD so much that he created this formula? And why was the OCD never mentioned? I was counting down the minutes for this boring, pointless film to just end.

The Perfect 46The Perfect 46 follows in a recent trend in science fiction, that is more interested in exploring the potential of human experience than actually depicting that future through CGI and fancy sets. The Perfect 46 offers new slant on this trend though; whereas the work of Shane Carruth, Gareth Edwards and Duncan Jones focuses on ordinary people dealing with future concepts. The Perfect 46 looks at the experience of the person who has invented the new 'thing' and who has to take responsibility for it when it fails. That person is Jesse Darden, creator of theperfect46.com: a website service which takes the genome sequence of you and your partner and tells you the likelihood of any future child inheriting a life altering condition. The film is an interesting mix of stories than depict Jesse's life in various different ways. Snapshots of his personal life and the business' development are contrasted with a tense and slightly sinister break-in at Jesse's home and the discovery, by one of the burglars, of a TV-style documentary about the company and Jesse (which does well to provide all the contextual information and science-fictionally elements of the plot). In combining these elements the film is able to convey a lot of information whilst still having the space to explore the impact of theperfect46.com in a more naturalistic way. The central example being an extended dinner party scene, where the guests challenge Jesse on his ideals and a technology conference where Jesse spells out his idealistic view of theperfect46.com.These aspects of the film are so unusual and well conceived that it is almost disappointing that the film takes a more emotional turn in the ending, revealing the motivation of one of the burglars is connected to a very personal experience. The Perfect 46 is a remarkably brave film that deals with the difficult topic of eugenics, calls into question the responsibility of the dotcom tycoons who have a significant affect on everyday lives and doing so without grandstanding special effects but with a naturalistic and intricate script and an outstanding central performance by Whit Hertford.